With four teams on bye this week (Chicago Bears, Denver Broncos, Philadelphia Eagles, Tampa Bay Buccaneers) and some key players set to miss time with injuries, let's look at potential pickups to fill holes in your lineup this week.
There are multiple ball carriers who can take advantage of opportunities in Week 10 due to injuries and elevated roles. Some will face tough matchups, but it's hard to find volume in deeper formats. The wide receiver spot has upside and some unknowns this week, and I went lighter on the quarterbacks, targeting just two superflex options.
Runnings backs
Audric Estime, New Orleans Saints (48.2% rostered; vs. Panthers)
Estime scored a season-high 14.7 fantasy points in the Week 9 win over the Browns, rushing 15 times for 72 yards and a touchdown and adding one reception for five yards. Alvin Kamara will still get his touches as a change-of-pace option and receiving back, but Estime is in line to lead the backfield in carries again versus a Panthers defense giving up 27.6 fantasy PPG to running backs (second most in the league). Take the matchup and the volume in this one with Estime.
Corey Kiner, New England Patriots (38.6% rostered; at Lions)
With Rhamondre Stevenson (knee) uncertain and TreVeyon Henderson (illness) out, Kiner's role will expand for Sunday's matchup against the Lions. Kiner scored a season-high 11.5 points in the Week 9 loss to Green Bay, rushing eight times for 55 yards and a touchdown. The Detroit defense allows the second-fewest fantasy points per game to running backs, but managers can play Kiner as a deeper-league flex option due to his anticipated usage.
Kaleb Johnson, Green Bay Packers (12.0% rostered; vs. Vikings)
Josh Jacobs' hand injury has opened the door for Johnson to see more volume. In the Week 9 win over the Patriots, Johnson scored 12.8 points, finishing with 68 yards rushing and a touchdown on 14 carries. While I don't love this matchup versus the Vikings defense, Johnson can handle early-down volume and managers in deeper formats can play him for goal-line usage here, too.
Dylan Sampson, Cleveland Browns (20.4% rostered; vs. Texans)
Sampson is the receiving back I like in Week 10. He has scored 10 or more points in two of his last three games, and he has at least three receptions in each. With the rushing volume he also sees, Sampson can give managers 8-10 touches versus Houston, and the pass-catching upside increases his value as a flex option.
Wide receivers
Jordyn Tyson, New Orleans Saints (41.2% rostered; vs. Panthers)
The rookie saw his first game action last week after suffering a hamstring injury in camp, catching all four of his targets for 30 yards versus the Browns. Tyson, who ran 16 routes in that game, could see his role increase this week against the Panthers. He has the playmaking traits to produce if given more volume. Tyson is a solid flex play this week in deeper formats.
Ryan Flournoy, Dallas Cowboys (27.4% rostered; vs. 49ers)
With George Pickens (hamstring) out last week versus the Colts, Flournoy caught just two of three targets for 53 yards, while CeeDee Lamb saw 16 targets. Not what I expected there. We'll monitor Pickens' status ahead of Sunday's game versus the 49ers, but let's manage expectations for Flournoy in this one. It's a tough matchup, too. I see him as a deeper-league WR3.
Caleb Douglas, Miami Dolphins (30.6% rostered; at Colts)
Quarterback Kyle McCord will make his first pro start Sunday with Malik Willis (groin) placed on IR. McCord has the deep-ball ability and touch to make plays down the field, so let's get Douglas in the mix. Douglas has scored 13 or more points in two of his last three games, and he can win at multiple levels of the field. Target Douglas as your deeper-league flier this week versus the Colts.
Tutu Atwell (10.3% rostered) and Konata Mumpfield (8.9% rostered), Los Angeles Rams (at Cardinals)
With both Puka Nacua (knee) and Davante Adams (hamstring) on IR, someone must emerge as a perimeter target for Matthew Stafford. I think Atwell provides more upside here given his vertical ability and open-field speed, while Mumpfield can operate as a possession target for Stafford off play-action and quick throws. Neither player has more than 15 receptions on the season, so there are some unknowns here, but the matchup versus Arizona is favorable, as the Cardinals have allowed 11 touchdowns to wide receivers (second most in the league).
Quarterbacks
Geno Smith, New York Jets (21.7% rostered; vs. Bills)
Smith had a season-low 7.4 fantasy points in the Week 9 loss to the Chiefs, but he scored 18 or more points (with multiple touchdown throws) in Weeks 7 and 8. I have Smith ranked as a midtier QB2 this week, so let's not get too excited. But he has enough value to fit in superflex lineups for the matchup with Buffalo.
Aaron Rodgers, Pittsburgh Steelers (36.4% rostered; at Bengals)
The Steelers' passing offense has lacked explosive ability in recent games. However, in the Week 4 matchup versus the Bengals, Rodgers scored 22.68 points, throwing for 292 yards and three touchdowns. Managers will need a similar game script, but Rodgers should see opportunities to push the ball to the third level of the field in this one. Rodgers fits as a superflex starter this week.
Tight end
Darren Waller, Carolina Panthers (21.3% rostered; at Saints)
In the Week 9 loss to Denver, Waller posted season highs in fantasy points (23), receptions (eight), targets (10) and yards (90). While managers shouldn't expect another breakout week for Waller, he has 12 or more points and a touchdown in two of his last three games, and the Saints rank in the bottom 10 versus tight ends. Play the matchup.
D/ST
Miami Dolphins (3.2% rostered; at Colts)
The Dolphins have at least two sacks and a forced turnover in three straight games, and they now get a Colts team that just traded away wide receivers Josh Downs and Keenan Allen. Expect them to play more single-high coverage and get extra numbers in the front to limit running back Jonathan Taylor. This is a quality matchup for the Dolphins, which makes them a good pickup for deeper-league managers.