Week 1 featured plenty of surprises, some ultra-high-scoring outputs and special individual performances.
What will Week 2 have in store? Action gets underway with Thursday with the Detroit Lions visiting the Buffalo Bills in a game that has the highest posted total listed for the week.
Several intriguing matchups follow Sunday, among them the Chicago Bears hosting the Minnesota Vikings, the Pittsburgh Steelers visiting the New England Patriots, the Denver Broncos taking on the Jacksonville Jaguars and the Houston Texans facing the Cincinnati Bengals
Action wraps up with the Los Angeles Rams looking to rebound from a disappointing Week 1 when hosting the New York Giants on "Monday Night Football" (8:15 ET on ABC/ESPN).
Here's a look at the odds for every Week 2 game. You can find our early bets for the week here.
Note: Odds by DraftKings
and subject to change.
Jump to:
DET-BUF | MIN-CHI | CLE-TB | PHI-TEN
CAR-ATL | GB-NYJ | PIT-NE | NO-BAL
CIN-HOU | LV-LAC | JAX-DEN | MIA-SF
SEA-ARI | WSH-DAL | IND-KC | NYG-LAR
Detroit Lions vs. Buffalo Bills -3.5
Thursday, 8:15 p.m., Prime Video
Moneyline: Lions (+154); Bills (-185)
Total: 53.5; Opened: 52.5
FPI favorite: Bills by 4.2 with a 64% probability to win outright
Minnesota Vikings vs. Chicago Bears -5.5
Sunday, 1 p.m., Fox
Line movement: Opened Bears -3.5
Moneyline: Vikings (+205); Bears (-250)
Total: 49.5; Opened: 45.5
FPI favorite: Bears by 2.6 with a 59% probability to win outright
Cleveland Browns vs. Tampa Bay Buccaneers -8.5
Sunday, 1 p.m., CBS
Line movement: Opened Buccaneers -5.5
Moneyline: Browns (+295); Buccaneers (-375)
Total: 40.5; Opened: 42.5
FPI favorite: Buccaneers by 8.3 with a 78% probability to win outright
Philadelphia Eagles -7 vs. Tennessee Titans
Sunday, 1 p.m., Fox
Line movement: Opened Eagles -4.5
Moneyline: Eagles (-310); Titans (+250)
Total: 40.5; Opened: 42.5
FPI favorite: Eagles by 5.5 with a 70% probability to win outright
Carolina Panthers -1.5 vs. Atlanta Falcons
Sunday, 1 p.m., Fox
Line movement: Opened Falcons -1.5
Moneyline: Panthers (-125); Falcons (+110)
Total: 43.5; Opened: 43.5
FPI favorite: Falcons by 1.8 with a 57% probability to win outright
Green Bay Packers -4.5 vs. New York Jets
Sunday, 1 p.m., Fox
Line movement: Opened Packers -6.5
Moneyline: Packers (-225); Jets (+185)
Total: 44.5; Opened: 42.5
FPI favorite: Packers by 3.2 with a 62% probability to win outright
Pittsburgh Steelers vs. New England Patriots -5.5
Sunday, 1 p.m., CBS
Moneyline: Steelers (+195); Patriots (-238)
Total: 41.5; Opened: 43.5
FPI favorite: Patriots by 4.2 with a 66% probability to win outright
New Orleans Saints vs. Baltimore Ravens -8.5
Sunday, 1 p.m., CBS
Moneyline: Saints (+295); Ravens (-375)
Total: 47.5; Opened: 46.5
FPI favorite: Ravens by 7.7 with a 77% probability to win outright
Cincinnati Bengals vs. Houston Texans -3
Sunday, 1 p.m., CBS
Moneyline: Bengals (+124); Texans (-148)
Total: 46.5; Opened: 46.5
FPI favorite: Texans by 1.1 with a 56% probability to win outright
Las Vegas Raiders vs. Los Angeles Chargers -7
Sunday, 4:05 p.m., CBS
Moneyline: Raiders (+235); Chargers (-290)
Total: 44.5; Opened: 42.5
FPI favorite: Chargers by 5.6 with a 69% probability to win outright
Jacksonville Jaguars vs. Denver Broncos -2.5
Sunday, 4:05 p.m., CBS
Moneyline: Jaguars (+124); Broncos (-148)
Total: 43.5; Opened: 44.5
FPI favorite: Jaguars by 0.8 with a 53% probability to win outright
Miami Dolphins vs. San Francisco 49ers -12.5
Sunday, 4:25 p.m., Fox
Line movement: Opened 49ers -10.5
Moneyline: Dolphins (+600); 49ers (-900)
Total: 46.5; Opened: 46.5
FPI favorite: 49ers by 14.3 with a 91% probability to win outright
Seattle Seahawks -4.5 vs. Arizona Cardinals
Sunday, 4:25 p.m., Fox
Line movement: Opened Seahawks -10
Moneyline: Seahawks (-225); Cardinals (+185)
Total: 41.5; Opened: 44.5
FPI favorite: Cardinals by 1 with a 54% probability to win outright
Washington Commanders vs. Dallas Cowboys -3.5
Sunday, 4:25 p.m., Fox
Moneyline: Commanders (+164); Cowboys (-198)
Total: 50.5; Opened: 51.5
FPI favorite: Cowboys by 3.8 with a 64% probability to win outright
Indianapolis Colts vs. Kansas City Chiefs -6.5
Sunday, 8:20 p.m., NBC
Moneyline: Colts (+235); Chiefs (-290)
Total: 48.5; Opened: 47.5
FPI favorite: Chiefs by 5.7 with a 70% probability to win outright
New York Giants vs. Los Angeles Rams -7
Monday, 8:15 p.m., ESPN, ABC
Moneyline: Giants (+275); Rams (-345)
Total: 48.5; Opened: 47.5
FPI favorite: Rams by 4.5 with a 66% probability to win outright