EL SEGUNDO, Calif. -- The Los Angeles Chargers placed safety Derwin James Jr. on injured reserve with a hamstring injury on Saturday.
The Pro Bowl safety hasn't played since a loss at Buffalo on Sept. 27. The move wasn't unexpected after coach Jim Harbaugh said this week that James suffered a setback in his rehab and recovery.
James will have to sit out a minimum of four games for the Chargers (0-6), who face the Los Angeles Rams (3-4) on Sunday.
The Chargers signed cornerback Isas Waxter to the active roster and promoted cornerback Kaiir Elam from the practice squad.
In addition to James, left guard Kayode Awosika will miss a fifth straight game because of a leg injury. Defensive back Deane Leonard (concussion) and wide receiver Brenen Thompson (quad/hamstring) also were ruled out.
Waxter spent last season on the Bolts' practice squad after initially signing as an undrafted free agent with Seattle. He has appeared in a pair of games this season as a standard elevation.
Elam has started 19 of 43 career regular-season games with Buffalo, Dallas and Tennessee.