ESPN
    • NFL
    • NCAAF
    • MLB
    • NBA
    • Soccer
    • WNBA
    • NHL
    • More Sports
    • Watch ESPN
      Watch
    • ESPN Fantasy
      Fantasy
    • Where to Watch
    • Search

    New England Patriots @ Buffalo Bills

    NE
    New England PatriotsPatriotsNE
    1-2, 0-2 Away
    BUF
    Buffalo BillsBillsBUF
    3-0, 2-0 Home
    • Gamecast
    • Preview
    • Odds
    • TicketsExternal Link

    Game Odds
    Odds by

    2026-10-04T17:00ZOpenSpreadTotalML
    New England PatriotsNew England PatriotsNE
    (1-2)
    (1-2)
    o49.5
    -110
    +7
    -115
    o48.5
    -115
    +240
    Buffalo BillsBuffalo BillsBUF
    (3-0)
    (3-0)
    -3
    -110
    -7
    -105
    u48.5
    -105
    -298
    See More Odds

    Recent Schedule

    DATEOPPRESULTSPREADTOTAL
    9/27@JAXL35-6+346.5
    9/20vsPITW20-3-4.541.5
    9/09@SEAL13-10+344.5
    8/27@CLEL37-13-2.535.5
    8/22vsPHIW24-21+1.537.5

    Matchup Predictor

    New England Patriots
    Buffalo Bills
    29.3
    %

    NE

    70.5
    %

    BUF

    According to ESPN Analytics

    Betting 101

    The Beginner's Guide to BettingReady to enter the world of sports betting? Here's everything you need to know to get started.
    James Cook III
    BUF RB
    Josh Allen
    BUF QB
    Dalton Kincaid
    BUF TE
    DJ Moore
    BUF WR
    Rhamondre Stevenson
    NE RB
    TreVeyon Henderson
    NE RB
    Khalil Shakir
    BUF WR
    Hunter Henry
    NE TE
    FIRST TD
    Anytime TD
    2+ TDs
    +500
    -130
    +425
    +600
    -130
    +475
    +950
    +170
    +1300
    +950
    +150
    +1200
    +950
    +140
    +950
    +1200
    +205
    +1700
    +1300
    +230
    +2000
    +1700
    +255
    +2200
    See More Odds
    Drake Maye
    NE QB
    22+
    24+
    26+
    28+
    30+
    31+
    32+
    +110
    34+
    36+
    38+
    40+
    42+
    Josh Allen
    BUF QB
    22+
    24+
    26+
    28+
    30+
    -104
    32+
    34+
    36+
    38+
    40+
    See More Odds
    Josh Allen
    BUF QB
    Drake Maye
    NE QB
    o242.5
    -111
    u242.5
    -113
    o232.5
    -111
    u232.5
    -113
    See More Odds
    James Cook III
    BUF RB
    TreVeyon Henderson
    NE RB
    Rhamondre Stevenson
    NE RB
    Josh Allen
    BUF QB
    o87.5
    -113
    u87.5
    -111
    o40.5
    -112
    u40.5
    -112
    o32.5
    -112
    u32.5
    -112
    o31.5
    -116
    u31.5
    -109
    See More Odds
    Dalton Kincaid
    BUF TE
    DJ Moore
    BUF WR
    Mack Hollins
    NE WR
    Romeo Doubs
    NE WR
    Khalil Shakir
    BUF WR
    Hunter Henry
    NE TE
    o52.5
    -114
    u52.5
    -110
    o48.5
    -114
    u48.5
    -110
    o43.5
    -115
    u43.5
    -109
    o40.5
    -113
    u40.5
    -111
    o38.5
    -113
    u38.5
    -111
    o30.5
    -110
    u30.5
    -114
    See More Odds
    Buffalo Bills
    3-0
    New England Patriots
    1-2
    o17.5
    -750
    u17.5
    +500
    o10.5
    -750
    u10.5
    +500
    See More Odds

    Injury Report

    New England Patriots
    NameStatus
    Eli RaridonE. RaridonTE
    QuestionableThigh
    Dre'Mont JonesD. JonesDE
    QuestionableShoulder
    Reggie GilliamR. GilliamFB
    QuestionableKnee
    Channing CanadaC. CanadaCB
    QuestionableHamstring
    Christian GonzalezC. GonzalezCB
    QuestionableShoulder
    Buffalo Bills
    NameStatus
    Christian BenfordC. BenfordCB
    QuestionableToe
    T.J. SandersT.J. SandersDT
    Questionable
    Keon ColemanK. ColemanWR
    QuestionableAnkle
    Sam Franklin Jr.S. Franklin Jr.S
    QuestionablePersonal
    DJ MooreD. MooreWR
    QuestionableShoulder
    Full Injury Report

    Super Bowl Winner

    TEAMODDS
    LARLAR+670
    BUFBUF+670
    BALBAL+900
    SFSF+900
    SEASEA+1000
    KCKC+1050
    PHIPHI+1700
    CINCIN+1700
    TEAMODDS
    DETDET+1900
    DENDEN+2000
    JAXJAX+2200
    NENE+2400
    CHICHI+2400
    MINMIN+2400
    DALDAL+2800
    HOUHOU+3500
    See More NFL Futures
    Top Betting Headlines
    • Wemby won't promote betting sites: 'I want to inspire in a good way'
    • Rozier's mother to court: Allow Terry to return to NBA
    • New York calls Polymarket 'unlicensed gambling operation' in lawsuit
    • Gators coach on being fave vs. Ole Miss: 'Lot of good drugs out there'
    • Federal prosecutors identify 18 allegedly rigged pitches for Clase trial
    • Leagues, unions urge action against escalating threats from bettors
    • Sweeney's Novig ad criticized for sexualizing women in sports
    • Zverev, Sabalenka favorites to win US Open titles
    • Super Bowl favorite Rams drawing the most bets
    • Allen, Jackson, Burrow lead NFL MVP faves; non-QBs top OROY odds
    ESPN
    • Terms of Use
    • Privacy Policy
    • Your US State Privacy Rights
    • Children's Online Privacy Policy
    • Interest-Based Ads
    • About Nielsen Measurement
    • Your Privacy Choices
    • Contact Us
    • Disney Ad Sales Site
    • Work for ESPN
    • Corrections
    GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Call 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/KY/NH/PR/WY). Void in ONT. Eligibility restrictions apply. Terms: draftkings.com/sportsbook. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL.
    Copyright: © 2026 ESPN Enterprises, LLC. All rights reserved.