NFL Week 10 betting odds: Lines and totals for every game

Brock Purdy and the 49ers visit the Cowboys in Week 10 in what is projected to be a high-scoring affair. AP Photo/Kelley L. Cox

Week 10 gets underway with the NFC East-leading New York Giants hosting the Washington Commanders on Thursday night at MetLife Stadium. These teams played to a 27-27 tie in Week 5 after a Commanders gaffe in overtime allowed time to expire. The Giants are slight favorites in the rematch.

The New England Patriots and Detroit Lions meet in Munich to get the Sunday slate started. The Jacksonville Jaguars are the biggest favorites of the week, laying 9.5 points Sunday afternoon on the road against the Tennessee Titans. The San Francisco 49ers-Dallas Cowboys matchup in the late afternoon window has the highest total (55.5).

The winless Los Angeles Chargers will visit the Baltimore Ravens on "Monday Night Football" (8:15 p.m. ET on ESPN) to close out the week.

The Chicago Bears, Denver Broncos, Philadelphia Eagles and Tampa Bay Buccaneers are on byes. Here's a look at the odds for every game this week.

Note: Odds by DraftKings and subject to change. All times Eastern.

Jump to:
WSH-NYG | NE-DET | BUF-NYJ | KC-ATL
MIA-IND | JAX-TEN | MIN-GB | CAR-NO
HOU-CLE | LAR-ARI | SEA-LV | SF-DAL
PIT-CIN | LAC-BAL


Washington Commanders vs. New York Giants -1.5
Thursday, 8:15 p.m., Prime Video


Moneyline: Commanders (+105); Giants (-125)
Total: 43.5; Opened: 47.5
FPI favorite: Commanders by 0.2 with a 51% probability to win the game outright


New England Patriots vs. Detroit Lions -2.5
Sunday, 9:30 a.m., Fox


Moneyline: Patriots (+120); Lions (-142)
Total: 50.5; Opened: 48.5
FPI favorite: Patriots by 0.4 with a 51% probability to win the game outright


Buffalo Bills -8.5 vs. New York Jets
Sunday, 1 p.m., CBS


Moneyline: Bills (-550); Jets (+410)
Total: 51.5; Opened: 46.5
FPI favorite: Bills by 7.6 with a 77% probability to win the game outright


Check out the latest Super Bowl odds and major NFL awards futures.


Kansas City Chiefs -3.5 vs. Atlanta Falcons
Sunday, 1 p.m., CBS


Moneyline: Chiefs (-180); Falcons (+150)
Total: 46.5; Opened: 45.5
FPI favorite: Chiefs by 6.1 with a 73% probability to win the game outright


Miami Dolphins vs. Indianapolis Colts -2.5
Sunday, 1 p.m., CBS


Moneyline: Dolphins (+110); Colts (-130)
Total: 41.5; Opened: 47.5
FPI favorite: Colts by 5.5 with a 71% probability to win the game outright


Jacksonville Jaguars -9.5 vs. Tennessee Titans
Sunday, 1 p.m., Fox


Moneyline: Jaguars (-500); Titans (+380)
Total: 46.5; Opened: 45.5
FPI favorite: Jaguars by 10 with an 84% probability to win the game outright


Minnesota Vikings vs. Green Bay Packers -3
Sunday, 1 p.m., Fox


Moneyline: Vikings (+142); Packers (-170)
Total: 42.5; Opened: 45.5
FPI favorite: Packers by 1.7 with a 57% probability to win the game outright


Carolina Panthers -1.5 vs. New Orleans Saints
Sunday, 1 p.m., Fox


Moneyline: Panthers (-120); Saints (+100)
Total: 47.5; Opened: 43.5
FPI favorite: Saints by 0.2 with a 51% probability to win the game outright


Houston Texans -4.5 vs. Cleveland Browns
Sunday, 1 p.m., Fox


Moneyline: Texans (-192); Browns (+160)
Total: 39.5; Opened: 38.5
FPI favorite: Texans by 5.5 with a 70% probability to win the game outright


Los Angeles Rams -7 vs. Arizona Cardinals
Sunday, 4:05 p.m., CBS


Moneyline: Rams (-310); Cardinals (+250)
Total: 45.5; Opened: 47.5
FPI favorite: Rams by 8.1 with a 79% probability to win the game outright


Seattle Seahawks -3 vs. Las Vegas Raiders
Sunday, 4:05 p.m., CBS


Moneyline: Seahawks (-166); Raiders (+140)
Total: 42.5; Opened: 43.5
FPI favorite: Seahawks by 3.6 with a 64% probability to win the game outright


San Francisco 49ers -4.5 vs. Dallas Cowboys
Sunday, 4:25 p.m., Fox


Moneyline: 49ers (-225); Cowboys (+185)
Total: 55.5; Opened: 52.5
FPI favorite: 49ers by 3.3 with a 63% probability to win the game outright


Pittsburgh Steelers vs. Cincinnati Bengals -3.5
Sunday, 8:20 p.m., NBC


Moneyline: Steelers (+142); Bengals (-170)
Total: 47.5; Opened: 47.5
FPI favorite: Bengals by 4.7 with a 68% probability to win the game outright


Los Angeles Chargers vs. Baltimore Ravens -4.5
Monday, 8:15 p.m., ESPN


Moneyline: Chargers (+154); Ravens (-185)
Total: 38.5; Opened: 48.5
FPI favorite: Chargers by 1.8 with a 57% probability to win the game outright