Week 6 gets underway with the Seattle Seahawks visiting the Denver Broncos on "Thursday Night Football." The defending champions are early 3-point favorites. It is one of seven games with a spread of three points or less.
Kicking off Sunday's play is an AFC South matchup between the Houston Texans and Jacksonville Jaguars in London (9:30 a.m. ET start).
The Los Angeles Rams are the biggest favorite of the week, laying 12.5 points at home versus the Arizona Cardinals. The total for the game is 52.5, one of four games with a total over 50.
The Dallas Cowboys, coming off a loss to the previously winless Tampa Bay Buccaneers, head to Lambeau Field to take on the Green Bay Packers on Sunday night, and the San Francisco 49ers host the Washington Commanders on "Monday Night Football" (8:15 p.m. ET on ESPN/ABC) to close out the week.
The Cincinnati Bengals, Detroit Lions, Miami Dolphins and Minnesota Vikings are on bye. Here's a look at the odds for every game this week. (You can find early bets we like here.)
Note: Odds by DraftKings and subject to change. All times Eastern.
Jump to:
SEA-DEN | HOU-JAX | CHI-ATL | TEN-IND
CAR-PHI | NYJ-NE | BAL-CLE | NO-NYG
PIT-TB | ARI-LAR | BUF-LV | LAC-KC
DAL-GB | WSH-SF


Seattle Seahawks -3 vs. Denver Broncos
Thursday, 8:15 p.m., Prime Video
Moneyline: Seahawks (-148); Broncos (+124)
Total: 41.5; Opened: 43.5
FPI favorite: Seahawks by 1.4 with a 55% probability to win the game outright

Houston Texans vs. Jacksonville Jaguars -3
Sunday, 9:30 a.m., NFL Network
Moneyline: Jaguars (-148); Texans (+124)
Total: 43.5; Opened: 41.5
FPI favorite: Jaguars by 3.6 with a 64% probability to win the game outright

Chicago Bears -3 vs. Atlanta Falcons
Sunday, 1 p.m., Fox
Moneyline: Bears (-175); Falcons (+145)
Total: 47.5; Opened: 47.5
FPI favorite: Bears by 5.6 with a 70% probability to win the game outright
Check out the latest Super Bowl odds and major NFL awards futures.

Tennessee Titans vs. Indianapolis Colts -7
Sunday, 1 p.m., Fox
Moneyline: Titans (+260); Colts (-325)
Total: 44.5; Opened: 48.5
FPI favorite: Colts by 5.4 with a 70% probability to win the game outright

Carolina Panthers vs. Philadelphia Eagles -1.5
Sunday, 1 p.m., CBS
Moneyline: Panthers (-102); Eagles (-118)
Total: 42.5; Opened: 43.5
FPI favorite: Panthers by 0.2 with a 50.5% probability to win the game outright

New York Jets vs. New England Patriots -7
Sunday, 1 p.m., CBS
Moneyline: Jets (+260); Patriots (-325)
Total: 44.5; Opened: 42.5
FPI favorite: Patriots by 6.7 with a 74% probability to win the game outright

Baltimore Ravens -4.5 vs. Cleveland Browns
Sunday, 1 p.m., Fox
Moneyline: Ravens (-230); Browns (+190)
Total: 40.5; Opened: 44.5
FPI favorite: Ravens by 6.5 with a 73% probability to win the game outright

New Orleans Saints -1.5 vs. New York Giants
Sunday, 1 p.m., Fox
Moneyline: Saints (-115); Giants (-105)
Total: 45.5; Opened: 45.5
FPI favorite: Saints by 4.5 with a 67% probability to win the game outright

Pittsburgh Steelers -3 vs. Tampa Bay Buccaneers
Sunday, 1 p.m., CBS
Moneyline: Steelers (-155); Buccaneers (+130)
Total: 40.5; Opened: 45.5
FPI favorite: Steelers by 3 with a 61% probability to win the game outright

Arizona Cardinals vs. Los Angeles Rams -12.5
Sunday, 4:05 p.m., Fox
Moneyline: Cardinals (+490); Rams (-675)
Total: 52.5; Opened: 46.5
FPI favorite: Rams by 11.3 with a 86% probability to win the game outright

Buffalo Bills -6 vs. Las Vegas Raiders
Sunday, 4:25 p.m., CBS
Moneyline: Bills (-258); Raiders (+210)
Total: 52.5; Opened: 47.5
FPI favorite: Bills by 3.7 with a 64% probability to win the game outright

Los Angeles Chargers vs. Kansas City Chiefs -8.5
Sunday, 4:25 p.m., CBS
Moneyline: Chargers (+285); Chiefs (-360)
Total: 42.5; Opened: 46.5
FPI favorite: Chiefs by 6.1 with a 72% probability to win the game outright

Dallas Cowboys vs. Green Bay Packers -1.5
Sunday, 8:20 p.m., NBC
Moneyline: Cowboys (-105); Packers (-115)
Total: 52.5; Opened: 51.5
FPI favorite: Cowboys by 3.4 with a 63% probability to win the game outright

Washington Commanders vs. San Francisco 49ers -7.5
Monday, 8:15 p.m., ESPN, ABC
Moneyline: Commanders (+340); 49ers (-440)
Total: 50.5; Opened: 50.5
FPI favorite: 49ers by 11.2 with a 86% probability to win the game outright
