MLB Wild Card Round odds: The favorites for every series

Ronald Acuna Jr. and his Braves get the MLB playoffs started with a game against the Phillies on Tuesday afternoon. David J. Griffin/Icon Sportswire

The MLB Wild Card Round begins on Tuesday, Sept. 29 with a quartet of Game 1's.

Teams in this round play a best-of-three series, with all three games taking place in the home stadium of the better-seeded team. Those series are Chicago White Sox at Houston Astros, Boston Red Sox at New York Yankees, Philadelphia Phillies at Atlanta Braves and Chicago Cubs at San Diego Padres.

The two division winners with the best records in each league (Tampa Bay Rays, Cleveland Guardians, Milwaukee Brewers, Los Angeles Dodgers) all get a chance to rest their regulars and set up their rotations for the next round, where they'll square off with the winners beginning Saturday, Oct. 3.

For more on the MLB playoffs, check out each team's odds to win the World Series.

Odds by DraftKings and are accurate as of time of publication.


Chicago White Sox at Houston Astros
All games at Daikin Park


To win series: Astros −145, White Sox +125
Correct score for series: Astros 2-0 +235, Astros 2-1 +240
Correct score for series: White Sox 2-1 +300, White Sox 2-0 +300

Game 1: Tuesday, Sept. 29, 5 p.m. ET

Moneyline: Astros −136, White Sox +113
Run Line: Astros (-1.5) +158, White Sox (+1.5) -193
Over/Under 8.0 runs: O -110/U -110

Game 2: Wednesday, Sept. 30, 5 p.m. ET
*Game 3: Thursday, Oct. 1, 5 p.m. ET (if necessary)


Boston Red Sox at New York Yankees
All games at Yankee Stadium


To win series: Yankees −170, Red Sox +140
Correct score for series: Yankees 2-0 +185, Yankees 2-1 +240
Correct score for series: Red Sox 2-1 +320, Red Sox 2-0 +400

Game 1: Tuesday, Sept. 29, 8 p.m. ET

Moneyline: Yankees −154, Red Sox +127
Run Line: Yankees (-1.5) +153, Red Sox (+1.5) -186
Over/Under 6.5 runs: O -112/U -108

Game 2: Wednesday, Sept. 30, 8 p.m. ET
*Game 3: Thursday, Oct. 1, 8 p.m. ET (if necessary)


Philadelphia Phillies at Atlanta Braves
All games at Truist Park


To win series: Braves −125, Phillies +105
Correct score for series: Braves 2-0 +210, Braves 2-1 +290
Correct score for series: Phillies 2-1 +225, Phillies 2-0 +380

Game 1: Tuesday, Sept. 29, 2 p.m. ET

Moneyline: Braves −200, Phillies +163
Run Line: Braves (-1.5) +119, Phillies (+1.5) -143
Over/Under 6.5 runs: O -122/U +102

Game 2: Wednesday, Sept. 30, 2 p.m. ET
*Game 3: Thursday, Oct. 1, 2 p.m. ET (if necessary)


Chicago Cubs at San Diego Padres
All games at Petco Park


To win series: Padres −120, Cubs +100
Correct score for series: Padres 2-0 +260, Padres 2-1 +245
Correct score for series: Cubs 2-1 +290, Cubs 2-0 +275

Game 1: Tuesday, Sept. 29, 10 p.m. ET

Moneyline: Padres −127, Cubs +106
Run Line: Padres (-1.5) +167, Cubs (+1.5) -204
Over/Under 7.0 runs: O -119/U -101

Game 2: Wednesday, Sept. 30, 10 p.m. ET
*Game 3: Thursday, Oct. 1, 10 p.m. ET (if necessary)