England boss Thomas Tuchel said it would be "madness" to rest key players and will not take calls from Premier League managers about it.
Saturday's 3-2 defeat to Spain is followed up by three more Nations League fixtures in quick succession, with Tuesday's match in Czechia followed by a trip to Croatia at the weekend.
Next Tuesday's Wembley encounter against Czechia completes the new extended window, which puts a toll on players who have had truncated summers due to the World Cup.
However, Tuchel says they cannot afford to take their foot off the gas as Group A3 continues in Prague.
"No, I don't take calls from Premier League managers," the former Chelsea boss said. "I never called any national team coach. It is what it is.
"I cannot manage the players. It's just impossible. I knew as a club coach -- when I was on the other side -- that I had this example many times.
"If I would call a coach in Brazil or Argentina, they would not know what I am talking about. The players would not know what I am talking about.
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"So why would I do this and start giving the players the impression that it's OK to take a step back or share a half or to rest one match? Why would I?
"I would never. It's madness. We want to win the next match."