England duo Immanuel Feyi-Waboso and Tom Curry will miss the rest of the Nations Championship through injury while Seb Atkinson, Ollie Chessum and George Furbank will sit out the match on Saturday against Japan.
England's resources are being tested ahead of the clash with Eddie Jones' side at the weekend and the news of Feyi- Waboso and Curry's injuries will come as a blow to Steve Borthwick.
Both are key players and Feyi-Waboso dazzled in the first half against the Wallabies at the weekend.
Feyi-Waboso will miss the rest of the November Tests with an ankle injury, while Curry picked up a hip injury in training last week and will also be unavailable for this series of matches.
Atkinson (hip), Chessum (shoulder) and Furbank (groin) will all sit out the match with Japan but sources have told ESPN that all three are likely to be fit for the New Zealand match.
Borthwick has added six players to the 36-player squad with Newcastle Red Bull's Max Hicks, Harlequins' Jack Kenningham, Saracens' Noah Caluori and Tobias Elliott, Northampton Saints' Archie McParland and Bath's Max Ojomoh all joining. Bristol Bears' Harry Randall drops out.
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