ESPN
    • NFL
    • NCAAF
    • MLB
    • NBA
    • Soccer
    • WNBA
    • NHL
    • More Sports
    • Watch ESPN
      Watch
    • ESPN Fantasy
      Fantasy
    • Where to Watch
    • Search

    Los Angeles Chargers @ Buffalo Bills

    LAC
    Los Angeles ChargersChargersLAC
    0-2, 0-0 Away
    BUF
    Buffalo BillsBillsBUF
    2-0, 1-0 Home
    • Gamecast
    • Preview
    • Videos
    • Odds
    • TicketsExternal Link

    Game Odds
    Odds by

    2026-09-27T17:00ZOpenSpreadTotalML
    Los Angeles ChargersLos Angeles ChargersLAC
    (0-2)
    (0-2)
    o48.5
    -110
    +7
    -108
    o50.5
    -105
    +260
    Buffalo BillsBuffalo BillsBUF
    (2-0)
    (2-0)
    -2.5
    -110
    -7
    -112
    u50.5
    -115
    -325
    See More Odds

    Recent Schedule

    DATEOPPRESULTSPREADTOTAL
    9/20vsLVL26-14-6.543.5
    9/13vsARIL26-14-8.547.5
    8/27vsLARL20-18-3.537.5
    8/20vsSFL41-17-1.538.5
    8/13@HOUW27-7+1.538.5

    Matchup Predictor

    Los Angeles Chargers
    Buffalo Bills
    21.7
    %

    LAC

    78.2
    %

    BUF

    According to ESPN Analytics

    Betting 101

    The Beginner's Guide to BettingReady to enter the world of sports betting? Here's everything you need to know to get started.
    James Cook III
    BUF RB
    Josh Allen
    BUF QB
    Omarion Hampton
    LAC RB
    DJ Moore
    BUF WR
    Dalton Kincaid
    BUF TE
    Khalil Shakir
    BUF WR
    Ladd McConkey
    LAC WR
    Quentin Johnston
    LAC WR
    FIRST TD
    Anytime TD
    2+ TDs
    +400
    -190
    +295
    +550
    -135
    +400
    +550
    -125
    +450
    +950
    +165
    +1200
    +1100
    +185
    +1500
    +1100
    +195
    +1600
    +1600
    +210
    +1900
    +1900
    +270
    +2500
    See More Odds
    Josh Allen
    BUF QB
    Justin Herbert
    LAC QB
    o239.5
    -111
    u239.5
    -113
    o225.5
    -111
    u225.5
    -113
    See More Odds
    James Cook III
    BUF RB
    Omarion Hampton
    LAC RB
    Josh Allen
    BUF QB
    Justin Herbert
    LAC QB
    o78.5
    -112
    u78.5
    -112
    o61.5
    -109
    u61.5
    -115
    o34.5
    -113
    u34.5
    -111
    o19.5
    -111
    u19.5
    -113
    See More Odds
    Dalton Kincaid
    BUF TE
    Ladd McConkey
    LAC WR
    DJ Moore
    BUF WR
    Khalil Shakir
    BUF WR
    Oronde Gadsden
    LAC TE
    Quentin Johnston
    LAC WR
    o56.5
    -114
    u56.5
    -110
    o54.5
    -114
    u54.5
    -110
    o47.5
    -113
    u47.5
    -111
    o39.5
    -114
    u39.5
    -110
    o37.5
    -109
    u37.5
    -115
    o35.5
    -110
    u35.5
    -114
    See More Odds
    Buffalo Bills
    2-0
    Los Angeles Chargers
    0-2
    o19.5
    -750
    u19.5
    +550
    o10.5
    -800
    u10.5
    +550
    See More Odds

    Injury Report

    Los Angeles Chargers
    NameStatus
    Dalvin TomlinsonD. TomlinsonDT
    DoubtfulHamstring
    Elijah MoldenE. MoldenCB
    QuestionableHamstring
    Brenen ThompsonB. ThompsonWR
    QuestionableQuadriceps
    Tuli TuipulotuT. TuipulotuLB
    QuestionableHamstring
    Rodney ShelleyR. ShelleyCB
    QuestionableHamstring
    Buffalo Bills
    NameStatus
    DJ MooreD. MooreWR
    QuestionableShoulder - AC Joint
    Keon ColemanK. ColemanWR
    QuestionableAnkle
    Ed OliverE. OliverDT
    QuestionableHip
    T.J. SandersT.J. SandersDT
    Questionable
    Ar'maj Reed-AdamsA. Reed-AdamsG
    QuestionableElbow
    Full Injury Report

    Super Bowl Winner

    TEAMODDS
    LARLAR+650
    BUFBUF+750
    BALBAL+950
    SEASEA+1000
    SFSF+1100
    KCKC+1200
    PHIPHI+1600
    CINCIN+1700
    TEAMODDS
    DETDET+2000
    NENE+2000
    DENDEN+2000
    HOUHOU+2200
    DALDAL+2400
    GBGB+2500
    JAXJAX+2500
    MINMIN+2800
    See More NFL Futures
    Top Betting Headlines
    • Rozier's mother to court: Allow Terry to return to NBA
    • New York calls Polymarket 'unlicensed gambling operation' in lawsuit
    • Gators coach on being fave vs. Ole Miss: 'Lot of good drugs out there'
    • Federal prosecutors identify 18 allegedly rigged pitches for Clase trial
    • Leagues, unions urge action against escalating threats from bettors
    • Sweeney's Novig ad criticized for sexualizing women in sports
    • Zverev, Sabalenka favorites to win US Open titles
    • Super Bowl favorite Rams drawing the most bets
    • Allen, Jackson, Burrow lead NFL MVP faves; non-QBs top OROY odds
    • NFL betting expected to slow at U.S. sportsbooks
    ESPN
    • Terms of Use
    • Privacy Policy
    • Your US State Privacy Rights
    • Children's Online Privacy Policy
    • Interest-Based Ads
    • About Nielsen Measurement
    • Your Privacy Choices
    • Contact Us
    • Disney Ad Sales Site
    • Work for ESPN
    • Corrections
    GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Call 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/KY/NH/PR/WY). Void in ONT. Eligibility restrictions apply. Terms: draftkings.com/sportsbook. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL.
    Copyright: © 2026 ESPN Enterprises, LLC. All rights reserved.