CLEVELAND -- Carlos Santana hit a three-run homer, Francisco Lindor added a two-run shot and the Cleveland Indians salvaged the finale of a four-game series with Minnesota 9-2 on Thursday.

The AL Central-leading Indians were outscored 35-16 by the last-place Twins in the first three games. Cleveland is 5-8 against Minnesota and 26-8 against the rest of the division.

Santana homered in the third off Hector Santiago (10-5), who made his first start with the Twins since being acquired from the Angels on Monday.

Lindor homered in Cleveland's three-run seventh. Jason Kipins hit his career-high 18th home run, a solo shot in the first. Jose Ramirez added a solo homer in the eighth.

Dan Otero (3-1), who worked out of a fifth-inning jam, retired all four hitters he faced. Andrew Miller, acquired from the Yankees on Sunday, struck out three in 1 1/3 innings.