EUGENE, Ore. -- Joseph Young scored 21 points, including a key 3-pointer that touched off a 12-0 Oregon run midway through the second half, and the Ducks defeated the USC Trojans 78-66 on Saturday night.

Jason Calliste had 18 points for Oregon (15-6, 3-6 Pac-12), which led by as many as 17 points. The Ducks had lost six of their last seven games after opening the season with 13 straight wins and climbing as high as No. 10 in the AP rankings.

The Ducks had 16 steals, finishing just one shy of the school record. Young had a career-high six.

Byron Wesley finished with 19 points for the Trojans (10-12, 1-8 Pac-12), who have lost three straight overall and haven't managed to defeat the Ducks in seven straight meetings.

Sitting last in the league standings, Southern California was coming off a 76-75 loss to Oregon State on Thursday night. With the loss to the Ducks, the Trojans fall to 0-5 on the road in conference play.

USC was plagued by turnovers, finishing with a season-high 22.

The Trojans jumped out to a 12-6 lead on Wesley's jumper, but Oregon responded with a 7-0 run capped by Young's layup and free throw to take a 13-12 lead at the halfway point of the first period.

Oregon extended the lead to 23-18 on Mike Moser's 3-pointer.

USC tied it at 25 after Pe'Shon Howard's 3-pointer, but the Trojans didn't pull back in front until J.T. Terrell made a pair of free throws and Omar Araby dunked to go ahead 31-28.

Southern California led 38-34 at the break, but Young's 3-pointer, four straight points from Calliste and Ben Carter's layup gave Oregon a 53-44 lead with 12:02 left. Richard Amardi made a free throw and Johnathan Loyd scored a layup to complete the 11-point run that put the Ducks in command.

The Ducks, coming off a 70-68 loss to UCLA on Thursday night, went into the game ranked atop the Pac-12 and fourth in the nation with an average of 85.1 points per game.

The game was played on Phil Knight appreciation night at Matthew Knight Arena. All fans were given a souvenir bobblehead of the Nike co-founder, who was celebrating his 76th birthday. During a timeout, the fans serenaded their most famous booster with "Happy Birthday."