With the World Cup quarterfinals under way, teams will have already played at least five matches -- some that have stretched into extra time and penalties, while balancing the demands of criss-crossing North America.
Managers are anxiously awaiting the latest fitness updates before naming their starting XIs for the biggest games of the tournament.
ESPN are tracking the key injury concerns and availability news as the race for the semifinals intensifies.
Aurélien Tchouaméni, France
Quarterfinal: Morocco, Foxborough, July 9
Injury: Groin problem
Tchouaméni was forced to leave training in the run-up to France's round-of-16 clash against Paraguay. He was replaced by Manu Koné in midfield, who started alongside Adrien Rabiot against the South American side.
The 26-year-old was named on the bench for France's quarterfinal win over Morocco and was not introduced by Deschamps. Whether that was because he was not fit to play or there was no point in risking him after Kylian Mbappé and Ousmane Dembélé made the game safe midway through the second half.
Yéremy Pino, Spain
Quarterfinal: Belgium, Los Angeles, July 10
Injury: Collar bone
In a cruel twist for Spain boss Luis de la Fuente, both Pino and Nico Williams came off injured in the same match -- the group stage closer vs. Uruguay.
Pino landed awkwardly on his collar bone after a fall and was seen leaving the stadium in a sling.
"But the worst thing is the huge pain we feel with Yéremy, who could miss the rest of the World Cup," de la Fuente said at the time.
Reece James, England
Quarterfinal: Norway, Miami Gardens, July 10
Injury: Hamstring soreness
James missed England team training on Wednesday in Kansas, instead following an individual programme ahead of Saturday's World Cup quarterfinal against Norway.
The right-back started England's first two matches of the tournament but felt soreness in his hamstring after the 0-0 draw with Ghana. His absence is a concern for Thomas Tuchel, with the Three Lions already short on options at right-back.
James returned to England training the day before facing Erling Haaland and Co. in Miami.
Marc Guéhi, England
Quarterfinal: Norway, Miami Gardens, July 10
Injury: Fitness
Guéhi missed England team training on Wednesday in Kansas and instead completed what the FA described as an "individual programme."
The defender played the full 90 minutes in England's 3-2 round-of-16 win over Mexico on Sunday, and like James, Guéhi returned to training on Friday.
Tuchel hopes to have him fit to take on his Manchester City teammate Erling Haaland on July 10.
Declan Rice, England
Quarterfinal: Norway, Miami Gardens, July 10
Injury: Fitness
Rice also missed England's group session on Wednesday, completing an individual programme before returning to training 24 hours before Saturday's quarterfinal against Norway.
The midfielder played the full round-of-16 win over Mexico and even filled in at right-back late on against Congo DR earlier in the tournament.
After the win over Congo DR in the group stage, Rice said that he had battling "terrible pain."
Jordan Henderson, England
Quarterfinal: Norway, Miami Gardens, July 10
Injury: Arm fracture
One of the most bizarre injuries of the tournament, Henderson broke his arm during post-match celebrations after England beat Mexico 3-2 in the round of 16, ending his tournament.
The 36-year-old was an unused substitute, but fell off the advertising hoarding when the squad went over to start the festivities with travelling supporters behind the goal.
He successfully underwent surgery on his arm and will remain with the squad in Kansas.
Information from ESPN's Tom Hamilton, Rob Dawson and Alex Kirkland was used in this report.