Arizona Cardinals @ San Francisco 49ers

1-1, 1-0 Away

2-0, 1-0 Home

49ers coach Kyle Shanahan faces another disciple in game against Cardinals coach Mike LaFleur

— San Francisco 49ers coach Kyle Shanahan said he might appreciate one day how many assistants that used to work under him have become head coaches in the NFL.

Sep 24, 2026, 05:32 pm - AP

Season Leaders

ARI

Passing Yards

Rushing Yards

Receiving Yards

Sacks

Tackles

Injury Report

Arizona Cardinals

Name	Status	Est. Return
Max MeltonM. MeltonCB	QuestionableToe	Sep 27
Dadrion Taylor-DemersonD. Taylor-DemersonS	QuestionableBack	Sep 27
Garrett WilliamsG. WilliamsCB	QuestionableAchilles	Sep 27
Hjalte FroholdtH. FroholdtC	QuestionableKnee	Sep 27
Roy LopezR. LopezDT	QuestionableGroin	Sep 27

San Francisco 49ers

Name	Status	Est. Return
Romello HeightR. HeightDE	QuestionableHand	Sep 27
Nick BosaN. BosaDE	QuestionableCalf	Sep 27
Mike EvansM. EvansWR	QuestionableHip	Sep 27
C.J. WestC.J. WestDT	IRUndisclosed	Oct 25
James Thompson Jr.J. Thompson Jr.DT	DoubtfulAnkle	Sep 27

Cardinals

DATE	OPP	RESULT
9/20/26	vsSEA	L31-7
9/13/26	@LAC	W26-14
8/28/26	@GB	L42-38
8/22/26	vsDAL	L34-13
8/13/26	@LV	W27-14

49ers

DATE	OPP	RESULT
9/20/26	vsMIA	W35-13
9/10/26	vsLAR	W27-7
8/27/26	@LV	W18-12
8/20/26	@LAC	W41-17
8/13/26	vsTEN	L19-13

Data is currently unavailable.

2026-09-27T20:05ZOpenSpreadTotalML

Arizona CardinalsCardinalsARI

(1-1)

(1-1, 1-0 Away)

o46.5

-110

San Francisco 49ers49ersSF

(2-0)

(2-0, 1-0 Home)

-11.5

-110

49ers vs CardinalsLevi's Stadium - Sun 9/27/26, 4:05Tickets as low as $83

Buy 49ers tickets with VividSeats

National Football Conference

NFC West	W	L	PCT	PF	PA
Seattle	2	0	1.000	44	17
San Francisco	2	0	1.000	62	20
Los Angeles	1	1	.500	35	33
Arizona	1	1	.500	33	45

NFL News

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Adam Rank catches you up on the vital information and insight needed to make tough lineup decisions in Week 3.

41m

Fantasy football last-minute pickups for Week 3: Stroud, Wicks, Spears among top options

If injuries or tough matchups have you seeking help, Matt Bowen provides options at each key position.

Don't be surprised if ... Kelce, Adams keep turning back the clock, Herbert rebounds

Eric Karabell provides a list of what to watch for in fantasy football, so don't be surprised if any of these come true.

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